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Piperazine → 3-Chloro-4-(piperazin-1-yl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Chloro-4-fluorobenzonitrile | HCID 145525 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-Chloro-4-(piperazin-1-yl)benzonitrile | HCID 19367113 | — |
反応手順
A solution of 3-chloro-4-fluoro-benzonitrile (236 mg, 1.52 mmoles), piperazine (784 mg, 9.1 mmoles) and potassium carbonate (276 mg, 2 mmoles) in acetonitrile (5 mL) was heated to 100° C. overnight. The mixture was cooled, filtered and the filtrate concentrated under reduced pressure. The crude residue was purified by column chromatography (silica gel, 0-5% 2N methanolic ammonia in DCM) to provide the title compound. MS(APCI+) m/z 222 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07880001B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-140b23027ee3474aaa6d1ed76ba30d60 |
| 出典メモ | uspto-grants-2011_02 |