Skatole → 1,2,7-trimethyl-1H-indole

反応式

[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH3:11].[CH3:12]C1C2C(=CC=CC=2)NC=1>>[CH3:12][N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[CH3:11])[CH:10]=[C:2]1[CH3:1]

参加物

反応物 2

HCID 6736Skatole

HCID 2598352,7-dimethyl-1H-indole

生成物 1

HCID 221390881,2,7-trimethyl-1H-indole収率 87%

実験手順

According to the procedure of Preparation 13 (a), except substituting 2,7-dimethylindole for the 3-methylindole, the title compound (960 mg, 87%) was obtained as an oil: MS (ES) m/e 160.2 (M+H)+.

出典と根拠

ORDレコード: ord-68cfdc1a1a444149be140d705891f560
出典データセット: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07879872B2

反応ノート

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