Bromine → 2-Amino-5-bromonicotinaldehyde hydrobromide
反応式
[Br:1]Br.[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>CC(O)=O>[BrH:1].[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][C:7]([Br:1])=[CH:6][N:5]=1参加物
4
実験手順
Bromine (1.1 mL, 20 mmol) in HOAc (20 mL) was added dropwise to a solution of 2-amino-pyridine-3-carbaldehyde (2.5 g, 20 mmol) in HOAc (50 mL) while stirring. After the addition, the mixture was allowed to stir for 2 h at room temperature. The precipitate was collected by filtration and washed with diethyl ether to afford the title compound (4.4 g, 77%) as a pale yellow solid: MS (ESI) m/e 201 (M+H)+.
後処理
- additionAfter the addition
- stirringto stir for 2 h at room temperature
- filtrationThe precipitate was collected by filtration
- washwashed with diethyl ether
出典と根拠
- ORDレコード
- ord-ba7f4ab0eeae41a5a20858331f3db4bd
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07879872B2
反応ノート
読み込み中…