methyl((1-methyl-1H-indol-2-yl)methyl)amine → HCID 66967165、化合物

HRID 1362218

反応式

HRID 1362218 の反応式
Cl.[CH2:2]([O:4][C:5]([CH2:7][N:8]1[CH2:13][C:12]2[CH:14]=[C:15](/[CH:18]=[CH:19]/[C:20]([OH:22])=O)[CH:16]=[N:17][C:11]=2[NH:10][C:9]1=[O:23])=[O:6])[CH3:3].Cl.[CH3:25][N:26]1[CH2:32][C:31]2[CH:33]=[C:34](/[CH:37]=[CH:38]/[C:39](O)=O)C=N[C:30]=2[NH:29][C:28](=O)[CH2:27]1.CNCC1N(C)C2C(C=1)=CC=CC=2.CNCC1C=CC2C(=CC=CC=2)C=1CCC>>[CH2:2]([O:4][C:5](=[O:6])[CH2:7][N:8]1[CH2:13][C:12]2[CH:14]=[C:15](/[CH:18]=[CH:19]/[C:20](=[O:22])[N:29]([CH3:30])[CH2:28][C:27]3[N:26]([CH3:25])[C:32]4[C:38]([CH:39]=3)=[CH:37][CH:34]=[CH:33][CH:31]=4)[CH:16]=[N:17][C:11]=2[NH:10][C:9]1=[O:23])[CH3:3]

参加物

5

反応物 4

HCID 11401058methyl((1-methyl-1H-indol-2-yl)methyl)amineHCID 59456959Methyl-(1-propyl-naphthalen-2-ylmethyl)amineHCID 66966197(E)-3-(4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)acrylic acid hydrochlorideHCID 66966906(E)-3-(3-ethoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)acrylic acid hydrochloride

生成物 1

HCID 66967165HCID 66967165、化合物収率 89%

実験手順

According to the procedure of Example 1 (a), except substituting (E)-3-(3-ethoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)acrylic acid hydrochloride for the (E)-3-(4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-7-yl)acrylic acid hydrochloride, and substituting methyl-(1-methyl-1H-indol-2-ylmethyl)amine for the methyl-(1-propyl-naphthalen-2-ylmethyl)amine, the title compound (1.20 g, 89%) was prepared as a tan solid and as a mixture of amide rotomers: 1H NMR (300 MHz, CDCl3) δ 8.34-8.28 (m, 1H), 7.66-7.34 (m, 2H), 7.60-7.53 (m, 2H), 7.33-7.21 (m, 2H), 7.11 (t, J=7.5 Hz, 1H), 6.83 (d, J=15.0 Hz, 1H), 6.50-6.40 (m, 1H), 4.93-4.30 (m, 2H), 4.59-4.52 (m, 2H), 4.27-4.19 (m, 4H), 3.71 (s, 3H), 3.13-3.06 (m, 3H), 1.30 (t, J=7.2 Hz, 3H); MS (ESI) m/e 462 (M+H)+.

出典と根拠

ORDレコード
ord-e2a306bdac7f4bf3aece0580d70719b6
出典データセット
uspto-grants-2011_02
特許番号
US07879872B2

関連ノート

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