HCID 12979373、化合物 → 3,7-Dimethyl-1H-indole-2-carbaldehyde
反応式
[CH3:1][C:2]1[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH2:12][OH:13]>ClCCl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[C:10]2[C:5](=[C:6]([CH3:11])[CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH:12]=[O:13]参加物
4
実験手順
A mixture of (3,7-dimethyl-1H-indol-2-yl)methanol (440 mg, 2.5 mmol) and manganese dioxide (1.09 g, 12.5 mmol) in dichloromethane (15 mL) was stirred overnight at rt. The mixture was filtered and evaporated. The crude was chromatographed over silica gel eluting with ethyl acetate/hexane (5% and 7.5%) to afford the title compound (200 mg, 46%). 1H NMR (400 MHz, CDCl3) δ 10.00 (s, 1H), 8.75 (s, 1H), 7.51 (d, J=7.2 Hz, 1H), 7.15 (d, J=7.4 Hz, 1H), 7.05 (t, J=7.3 Hz, 1H), 2.61 (s, 3H), 2.45 (s, 3H).
後処理
- filtrationThe mixture was filtered
- customevaporated
- customThe crude was chromatographed over silica gel eluting with ethyl acetate/hexane (5% and 7.5%)
出典と根拠
- ORDレコード
- ord-19ce02ad86e84093a10d65d6e56f850d
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07879872B2
反応ノート
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