(7-ethyl-3-methyl-1H-indol-2-yl)methanol → 7-ethyl-3-methyl-1H-indole-2-carbaldehyde

HRID 1362445ノート

反応式

HRID 1362445 の反応式
[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][C:9]([CH2:12][OH:13])=[C:8]2[CH3:14])[CH3:2]>ClCCl.[O-2].[Mn+4].[O-2]>[CH2:1]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][C:9]([CH:12]=[O:13])=[C:8]2[CH3:14])[CH3:2]

参加物

4

反応物 1

HCID 59277628(7-ethyl-3-methyl-1H-indol-2-yl)methanol

生成物 1

HCID 592775647-ethyl-3-methyl-1H-indole-2-carbaldehyde収率 65%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of (7-ethyl-3-methyl-1H-indol-2-yl)methanol (1.6 g, 9.1 mmol) and manganese (IV) oxide (3.97 g, 45.7 mmol) in dichloromethane (15 mL) was stirred overnight. The mixture was filtered through celite and evaporated to afford the title compound (1.1 mg, 65%). 1H NMR (400 MHz, CDCl3) δ 10.02 (s, 1H), 8.90 (s, 1H), 7.53 (d, J=8.0 Hz, 1H), 7.19 (d, J=7.6 Hz, 1H), 7.10 (t, J=7.7 Hz, 1H), 2.83 (q, J=7.5 Hz, 2H), 2.62 (s, 3H), 1.31 (t, J=7.5 Hz, 3H)

後処理

  1. filtrationThe mixture was filtered through celite
  2. customevaporated

出典と根拠

ORDレコード
ord-ba9849323a19496ba81e3a24ad1c1fbf
出典データセット
uspto-grants-2011_02
特許番号
US07879872B2

反応ノート

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