化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → (+)-trans-8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-2-(4-trifluoromethyl-phenyl)-chromen-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Methyl 4-(trifluoromethyl)benzoate | HCID 520447 | — |
| 反応物 | (-)-trans-1-[2-Hydroxy-3-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-4,6-dimethoxyphenyl]-1-ethanone | HCID 59318484 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (+)-trans-8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-2-(4-trifluoromethyl-phenyl)-chromen-4-one | HCID 66933632 | — |
反応手順
Compound of example 6 (1.5 g, 4.84 mmol) in dry DMF (15 mL) was reacted with methyl 4-trifluoromethylbenzoate (3.27 g, 16.02 mmol) in the presence of NaH (50%, 1.2 g, 25 mmol) as described in example 16, to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07884127B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-910d8171c19b4586b97e24f691c06dc4 |
| 出典メモ | uspto-grants-2011_02 |