Pyridinium chloride → (+)-trans-5,7-Dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-2-(4-trifluoromethyl-phenyl)-chromen-4-one

反応式

[OH:1][CH2:2][C@H:3]1[C@H:7]([C:8]2[C:9]([O:31]C)=[CH:10][C:11]([O:29]C)=[C:12]3[C:17]=2[O:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)=[CH:14][C:13]3=[O:28])[CH2:6][CH2:5][N:4]1[CH3:33].Cl.N1C=CC=CC=1>>[OH:29][C:11]1[CH:10]=[C:9]([OH:31])[C:8]([C@@H:7]2[CH2:6][CH2:5][N:4]([CH3:33])[C@H:3]2[CH2:2][OH:1])=[C:17]2[C:12]=1[C:13](=[O:28])[CH:14]=[C:15]([C:18]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=1)[O:16]2

参加物

反応物 2

HCID 10176127Pyridinium chloride

HCID 66933632(+)-trans-8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-2-(4-trifluoromethyl-phenyl)-chromen-4-one

生成物 1

HCID 66933731(+)-trans-5,7-Dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-2-(4-trifluoromethyl-phenyl)-chromen-4-one

実験手順

Compound of example 64 (0.7 g, 1.51 mmol) was demethylated using pyridine hydrochloride (7 g, 60.60 mmol) as described in example 17 to obtain the title compound.

出典と根拠

ORDレコード: ord-e4f19ee5eaf841a5be02ea5837097e75
出典データセット: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07884127B2

反応ノート

読み込み中…