Hydrochloric Acid → 2-Bromo-4-methoxybenzoic acid
反応式
[Br:1][C:2]1[CH:10]=[C:9]([N+]([O-])=O)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:14][O-:15].[Na+].Cl>CS(C)=O>[Br:1][C:2]1[CH:10]=[C:9]([O:15][CH3:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]参加物
5
実験手順
2-Bromo-4-nitrobenzoic acid (3 g, 12.2 mmol) was reacted with sodium methoxide (6 g, 111 mmol) in dry DMSO (250 mL) at 80° C. After completion of reaction mixture was poured over crushed ice, acidified with 1:1 HCl and extracted with EtOAc (3×150 mL). The organic layer was concentrated to obtain the title compound.
後処理
- customAfter completion of reaction mixture
- additionwas poured
- customover crushed ice
- extractionextracted with EtOAc (3×150 mL)
- concentrationThe organic layer was concentrated
出典と根拠
- ORDレコード
- ord-ccd2b7bdf5cc4372b3aaf2630c887c5f
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07884127B2
反応ノート
読み込み中…