Dimethylformamide → Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate

HRID 1363874ノート

反応式

HRID 1363874 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].[F:13][C:14]([F:27])([F:26])[C:15]1[CH:16]=[C:17]([OH:25])[CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1.CN(C)C=O.C(=O)([O-])[O-].[K+].[K+]>O>[F:13][C:14]([F:26])([F:27])[C:15]1[CH:16]=[C:17]([CH:18]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:20]=1)[O:25][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 676803,5-Bis(trifluoromethyl)phenolHCID 122490Ethyl 7-bromoheptanoate

生成物 1

HCID 86620562Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Ethyl 7-bromoheptanoate and 3,5-bis(trifluoromethyl) phenol were added to dimethylformamide (DMF). The solution was added with potassium carbonate and stirred at room temperature. The solution was added with water and extracted twice with ethyl acetate. After the organic layer was washed three times with water and dried over anhydrous magnesium sulfate, the solvent was removed. The residue was purified by silica gel column chromatography to obtain ethyl 7-(3,5-bis (trifluoromethyl)phenoxy)heptanoate.

後処理

  1. extractionextracted twice with ethyl acetate
  2. washAfter the organic layer was washed three times with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customthe solvent was removed
  5. customThe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-e8e04a83780f4898b380de6ef251f5f6
出典データセット
uspto-grants-2011_02
特許番号
US07887835B2

反応ノート

読み込み中…