HCID 63900315、化合物 → 2-Morpholin-4-ylsulfonylacetic acid
反応式
C[O:2][C:3](=[O:14])[CH2:4][S:5]([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1)(=[O:7])=[O:6]>C1CCCCC1.C(OCC)(=O)C>[N:8]1([S:5]([CH2:4][C:3]([OH:14])=[O:2])(=[O:7])=[O:6])[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1参加物
3
実験手順
(Morpholine-4-sulfonyl)acetic acid methyl ester (0.5 g, 2.24 mmol) is dissolved in 0.66 N KOH aqueous ethanol solution (1/1, 150 mL) and the mixture is heated at reflux during 16 h. The solvent is evaporated and residue is extracted with dichloromethane/methanol 4:1 to yield the title compound.
後処理
- temperaturethe mixture is heated
- temperatureat reflux during 16 h
- customThe solvent is evaporated
- extractionresidue is extracted with dichloromethane/methanol 4:1
出典と根拠
- ORDレコード
- ord-117390f3f3914bee9b79964ddae75a0b
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07888351B2
反応ノート
読み込み中…