Cyanoacetic acid → 2-Cyano-N-(2-methyl-6-nitrophenyl)acetamide
反応式
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-:11])=[O:10])[C:3]=1[NH2:4].[C:12]([CH2:14][C:15](O)=[O:16])#[N:13].P(Cl)(Cl)(Cl)(Cl)Cl>C1C=CC=CC=1>[C:12]([CH2:14][C:15]([NH:4][C:3]1[C:5]([N+:9]([O-:11])=[O:10])=[CH:6][CH:7]=[CH:8][C:2]=1[CH3:1])=[O:16])#[N:13]参加物
5
反応条件
- 温度
- 60 °C
実験手順
To a solution of 2-methyl-6-nitroaniline (25 g, 164.3 mmol) in benzene (200 mL) were added cyanoacetic acid (14.5 g, 170.46 mmol) and PCl5 (35 g, 168 mmol). The reaction mixture was heated at 60° C. for 7 h. After cooling to rt, the reaction mixture was filtered and the solid was washed with benzene and water. The solid was dried under reduced pressure to afford the title acetamide (24 g, 109 mmol) as a yellow solid.
後処理
- temperatureAfter cooling to rt
- filtrationthe reaction mixture was filtered
- washthe solid was washed with benzene and water
- customThe solid was dried under reduced pressure
出典と根拠
- ORDレコード
- ord-a5da6707aa424878a787301357002749
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07888359B2
反応ノート
読み込み中…