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Water → 7-Methoxy-2,3-dihydrobenzofuran-3-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ammonium Chloride | HCID 25517 | — |
| 反応物 | 7-Methoxybenzofuran-3(2H)-one | HCID 2818112 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 7-Methoxy-2,3-dihydrobenzofuran-3-ol | HCID 65721420 | 100% |
反応手順
To a cold (ice water) solution of 7-methoxy-3-(2H)-benzofuranone (846 mg; 5.0 mmol) in methanol (5 mL) is added sodium borohydride (179 mg; 5.0 mmol) is stirred for 15 minutes. Water (5 mL) is added to the solution and stirred 15 minutes. Saturated ammonium chloride (20 mL) is added and the solution is extracted with ethyl acetate. The organics are separated and dried over magnesium sulfate. The solvent is removed to give 831 milligrams of 7-methoxy-2,3-dihydrobenzofuran-3-ol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07888366B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-f638ed0f431b4ab7a44b77ffdd28ddb3 |
| 出典メモ | uspto-grants-2011_02 |