Water → 7-Methoxy-2,3-dihydrobenzofuran-3-ol

HRID 1364413

反応式

HRID 1364413 の反応式
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH2:9][C:8](=[O:12])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[BH4-].[Na+].O.[Cl-].[NH4+]>CO>[CH3:1][O:2][C:3]1[C:11]2[O:10][CH2:9][CH:8]([OH:12])[C:7]=2[CH:6]=[CH:5][CH:4]=1

参加物

6

反応物 4

HCID 962WaterHCID 25517Ammonium ChlorideHCID 28181127-Methoxybenzofuran-3(2H)-oneHCID 4311764Sodium borohydride

生成物 1

HCID 657214207-Methoxy-2,3-dihydrobenzofuran-3-ol収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a cold (ice water) solution of 7-methoxy-3-(2H)-benzofuranone (846 mg; 5.0 mmol) in methanol (5 mL) is added sodium borohydride (179 mg; 5.0 mmol) is stirred for 15 minutes. Water (5 mL) is added to the solution and stirred 15 minutes. Saturated ammonium chloride (20 mL) is added and the solution is extracted with ethyl acetate. The organics are separated and dried over magnesium sulfate. The solvent is removed to give 831 milligrams of 7-methoxy-2,3-dihydrobenzofuran-3-ol.

後処理

  1. stirringstirred 15 minutes
  2. extractionthe solution is extracted with ethyl acetate
  3. customThe organics are separated
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed

出典と根拠

ORDレコード
ord-f638ed0f431b4ab7a44b77ffdd28ddb3
出典データセット
uspto-grants-2011_02
特許番号
US07888366B2

関連ノート

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