Hydrochloric Acid → HCID 66924186、化合物

HRID 1364446ノート

反応式

HRID 1364446 の反応式
[Sn](Cl)Cl.Cl.[Cl:5][C:6]1[CH:24]=[CH:23][C:9]([O:10][CH2:11][C:12]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[C:13]=2[C:14]#[N:15])=[C:8]([CH3:25])[CH:7]=1.[OH-].[K+]>>[NH2:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:12]([CH2:11][O:10][C:9]2[CH:23]=[CH:24][C:6]([Cl:5])=[CH:7][C:8]=2[CH3:25])[C:13]=1[C:14]#[N:15]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 66924105HCID 66924105、化合物

生成物 1

HCID 66924186HCID 66924186、化合物収率 88%

反応条件

温度
15 °C

実験手順

To a cooled (15° C.) and stirred solution of tin (II) chloride (0.56 g, 2.48 mmol) and con. hydrochloric acid (2.0 mL) was added a solution of 2-(4-chloro-2-methylphenoxymethyl)-6-nitrobenzonitrile (150.0 mg, 0.5 mmol). The reaction mixture was slowly warmed to room temperature and stirred for 3 hours. The reaction mixture was poured on to crushed-ice and potassium hydroxide solution, stirred, extracted with dichloromethane, filtered and dried to yield 120 mg of 2-amino-6-(4-chloro-2-methylphenoxymethyl)benzonitrile.

後処理

  1. temperatureThe reaction mixture was slowly warmed to room temperature
  2. additionThe reaction mixture was poured on
  3. stirringstirred
  4. extractionextracted with dichloromethane
  5. filtrationfiltered
  6. customdried

出典と根拠

ORDレコード
ord-e058fba922e948b3842bd72eaddeb450
出典データセット
uspto-grants-2011_02
特許番号
US07888366B2

反応ノート

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