Hydrochloric Acid → HCID 24777029、化合物

HRID 1364456ノート

反応式

HRID 1364456 の反応式
[Sn](Cl)Cl.Cl.[F:5][C:6]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:7]=1[O:8][CH2:9][C:10]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[C:11]=1[C:12]#[N:13].[OH-].[K+]>>[NH2:18][C:14]1[CH:15]=[CH:16][CH:17]=[C:10]([CH2:9][O:8][C:7]2[CH:21]=[CH:22][C:23]([F:25])=[CH:24][C:6]=2[F:5])[C:11]=1[C:12]#[N:13]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 24479Stannous ChlorideHCID 24776912HCID 24776912、化合物

生成物 1

HCID 24777029HCID 24777029、化合物収率 91.5%

反応条件

温度
15 °C

実験手順

To a cooled (15° C.) and stirred solution of tin (II) chloride (0.37 g, 1.65 mmol) and con. hydrochloric acid (2.0 mL) was added a solution of 2-(2,4-difluorophenoxymethyl)-6-nitrobenzonitrile (160.0 mg, 0.55 mmol). The reaction mixture was slowly warmed to room temperature and stirred for 3 hours. The reaction mixture was poured on to crushed-ice and potassium hydroxide solution, stirred, extracted with dichloromethane, filtered and dried to yield 131 mg of 2-amino-6-(2,4-difluorophenoxymethyl)benzonitrile.

後処理

  1. temperatureThe reaction mixture was slowly warmed to room temperature
  2. additionThe reaction mixture was poured on
  3. stirringstirred
  4. extractionextracted with dichloromethane
  5. filtrationfiltered
  6. customdried

出典と根拠

ORDレコード
ord-ab1b91f807b441d49e1d3e1813658753
出典データセット
uspto-grants-2011_02
特許番号
US07888366B2

反応ノート

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