関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Fluoromandelic acid | HCID 98068 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(4-Fluorophenyl)ethane-1,2-diol | HCID 11412509 | 94.8% |
反応手順
To a stirred solution of 4-fluoromandelic acid (1.0 g, 5.88 mmol) in tetrahydrofuran was added lithium aluminum hydride (0.47 g, 12.34 mmol). The reaction mixture was refluxed for 1.5 hours. The reaction mixture was cooled (0° C.), quenched with sat. ammonium chloride solution, filtered, concentrated to yield 0.87 g of 1-(4-fluorophenyl)ethane-1,2-diol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07888366B2 |
|---|
| 出典データセット | uspto-grants-2011_02 |
|---|
| ORD ID | ord-103ede0fbc534f30a4002d2d742b0de8 |
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| 出典メモ | uspto-grants-2011_02 |
|---|
