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Trifluoroacetic acid → 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 4-Chloro-3-(pyridin-2-yl)aniline | HCID 40151925 | — |
| 反応物 | BOC-4-(aminomethyl)benzoic acid | HCID 66878017 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide | HCID 66877992 | — |
反応手順
Procedure G was used to couple BOC-4-(aminomethyl)benzoic acid (48 mg) with 4-chloro-3-(pyridin-2-yl)aniline (35 mg). The crude reaction mixture was treated with TFA (1 mL) containing trace amounts of water for 1 h. The reaction mixture was concentrated to yield 4-(aminomethyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07888364B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-61a403f8baa349dc8a2c4cba6315484b |
| 出典メモ | uspto-grants-2011_02 |