Hydrochloric Acid → HCID 58614830、化合物

HRID 1364820ノート

反応式

HRID 1364820 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.C(OC([N:22]1[CH2:27][CH2:26][CH:25]([CH2:28][C:29]2[CH:37]=[CH:36][C:32]([C:33](O)=[O:34])=[CH:31][CH:30]=2)[CH2:24][CH2:23]1)=O)(C)(C)C.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:33](=[O:34])[C:32]2[CH:31]=[CH:30][C:29]([CH2:28][CH:25]3[CH2:24][CH2:23][NH:22][CH2:27][CH2:26]3)=[CH:37][CH:36]=2)=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 115226074-({1-[(Tert-butoxy)carbonyl]piperidin-4-yl}methyl)benzoic acidHCID 401519254-Chloro-3-(pyridin-2-yl)aniline

生成物 1

HCID 58614830HCID 58614830、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

75 mg of 4-chloro-3-(pyridin-2-yl)aniline was coupled to 125 mg of 4-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)benzoic acid via Procedure G. The crude product was treated with 4N HCl in Dioxane, evaporated and purified by reverse phase HPLC to yield N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(piperidin-4-ylmethyl)benzamide. MS (Q1) 406.1 (M)+.

後処理

  1. customevaporated
  2. custompurified by reverse phase HPLC

出典と根拠

ORDレコード
ord-7a1f413bcfe64530bcbf25e80df13f03
出典データセット
uspto-grants-2011_02
特許番号
US07888364B2

反応ノート

読み込み中…