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HRID 1365247作成日：2026年10月27日

2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-(4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

https://huagongshe.com/reaction/1365247

反応式

関与物質

役割名称HCID仕込み量
反応物2-Aminopyrimidine-5-boronic acid, pinacol esterHCID 17750212—
反応物4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholineHCID 23650837—
生成物5-(4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amineHCID 46180604—

反応手順

(2-Chloro-6-((4-methylsulfonylpiperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine was reacted with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine via General Procedure B to give, after purification by reverse HPLC, 10 mg of 221. MS (Q1) 491 (M+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07888352B2
出典データセットuspto-grants-2011_02
ORD IDord-3a3888c76b7c4d0c989455be792d1b64
出典メモuspto-grants-2011_02