Hydrochloric Acid → (2R)-1-Methanesulfonyl-2-methylpiperazine hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([CH3:17])(=[O:16])=[O:15])[C@H:10]([CH3:18])[CH2:9]1)=O)(C)(C)C.[ClH:19]>ClCCl.C(OCC)C>[ClH:19].[CH3:17][S:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]1[CH3:18])(=[O:15])=[O:16]参加物
5
実験手順
To a solution of (R)-4-methanesulfonyl-3-methyl-piperazine-1-carboxylic acid tert-butyl ester (924 mg) in dichloromethane (20 mL) at 0° C. was added dropwise HCl (6.65 mL of a 2 M solution in diethyl ether). The reaction mixture was stirred at room temperature for 2 h. The precipitate formed was then collected by filtration and dried to afford (R)-1-methanesulfonyl-2-methyl-piperazine hydrochloride salt as a white solid (520 mg, 73%).
後処理
- customThe precipitate formed
- filtrationwas then collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-ca7483c489ae41b8ae87960e3ad0d0bf
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07888352B2
反応ノート
読み込み中…