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HRID 1365417作成日：2026年10月27日

2-Aminopyrimidine-5-boronic acid, pinacol ester → 2-(4-((2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanol

https://huagongshe.com/reaction/1365417

反応式

関与物質

役割名称HCID仕込み量
反応物2-Aminopyrimidine-5-boronic acid, pinacol esterHCID 17750212—
反応物2-(4-((2-Chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanolHCID 58233992—
生成物2-(4-((2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanolHCID 58233900—

反応手順

2-(4-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)piperazin-1-yl)ethanol (175 mg) was utilized in a Suzuki coupling with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine according to General Procedure Suzuki to provide 385 (20 mg) after reverse phase HPLC purification. MS (Q1) 457 (M)+

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07888352B2
出典データセットuspto-grants-2011_02
ORD IDord-f283d1cf86354df6aa6f20e44d000e08
出典メモuspto-grants-2011_02