Benzaldehyde → 2-Phenylbenzothiazole

HRID 1365592

反応式

HRID 1365592 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[CH:9](=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C1(C)C(C)=CC=CC=1>[C:10]1([C:9]2[S:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参加物

4

反応物 2

HCID 240BenzaldehydeHCID 87132-Aminothiophenol

生成物 1

HCID 134392-Phenylbenzothiazole

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

反応条件

温度
120 °C

実験手順

2-Aminothiophenol (0.856 ml, 8 mmol), benzaldehyde (0.813 ml, 8 mmol), 1 g of an oxidation catalyst and 15 ml of xylene as solvent were charged into a 100 ml three-neck flask, and were stirred at 120° C. for 13 hours under an oxygen atmosphere. The reaction mixture was filtered through Celite, and then the Celite and the oxidation catalyst were washed with ethyl acetate. The filtrate was condensed with a rotary evaporator to yield a solid. The solid was recrystallized from diethyl ether. Resulting colorless crystals were then weighed and the yield thereof was defined as a reaction yield.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. washthe Celite and the oxidation catalyst were washed with ethyl acetate
  3. customcondensed
  4. customwith a rotary evaporator
  5. customto yield a solid
  6. customThe solid was recrystallized from diethyl ether
  7. customResulting colorless crystals
  8. customthe yield
  9. customyield

出典と根拠

ORDレコード
ord-d61abc7cb7ff4475a705cec8cd41030f
出典データセット
uspto-grants-2011_02
特許番号
US07893004B2

関連ノート

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