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HRID 1365672作成日：2026年10月26日

2-(2,6-Dichlorobenzamido)pent-4-enoic acid methyl ester → (E)-2-(2,6-dichlorobenzamido)-5-[4-(tetrahydro-4-(methoxymethyl)-2H-pyran-4-yl)phenyl]pent-4-enoic acid methyl ester

https://huagongshe.com/reaction/1365672

反応式

関与物質

役割名称HCID仕込み量
反応物2-(2,6-Dichlorobenzamido)pent-4-enoic acid methyl esterHCID 57762518—
反応物tetrahydro-4-(4-bromophenyl)-4-(methoxymethyl)-2H-pyranHCID 57762592—
生成物(E)-2-(2,6-dichlorobenzamido)-5-[4-(tetrahydro-4-(methoxymethyl)-2H-pyran-4-yl)phenyl]pent-4-enoic acid methyl esterHCID 5776253374.2%

反応手順

In the same manner as in Example 1, 2-(2,6-dichlorobenzamido)pent-4-enoic acid methyl ester (78 mg) was reacted with tetrahydro-4-(4-bromophenyl)-4-(methoxymethyl)-2H-pyran (88 mg) to obtain (E)-2-(2,6-dichlorobenzamido)-5-[4-(tetrahydro-4-(methoxymethyl)-2H-pyran-4-yl)phenyl]pent-4-enoic acid methyl ester (97 mg). Column chromatography (silica gel, eluent: hexane/ethyl acetate=2/1) was used for purification.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07893046B2
出典データセットuspto-grants-2011_02
ORD IDord-02a93c87e04c44faad498813632b0cc2
出典メモuspto-grants-2011_02