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2-(2,6-Dichlorobenzamido)pent-4-enoic acid methyl ester → (E)-2-(2,6-dichlorobenzamido)-5-[4-(ethyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(2,6-Dichlorobenzamido)pent-4-enoic acid methyl ester | HCID 57762518 | — |
| 反応物 | N-(4-iodophenyl)-N-ethylpyrimidin-2-amine | HCID 57762566 | — |
| 生成物 | (E)-2-(2,6-dichlorobenzamido)-5-[4-(ethyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester | HCID 57762557 | 72.9% |
反応手順
In the same manner as in Example 1, 2-(2,6-dichlorobenzamido)pent-4-enoic acid methyl ester (214 mg) was reacted with N-(4-iodophenyl)-N-ethylpyrimidin-2-amine (254 mg) to obtain (E)-2-(2,6-dichlorobenzamido)-5-[4-(ethyl-pyrimidin-2-ylamino)phenyl]pent-4-enoic acid methyl ester (258 mg). Column chromatography (silica gel, eluent: hexane/ethyl acetate=4/1→hexane/ethyl acetate=2/1 hexane/ethyl acetate=1/2) was used for purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07893046B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-af4d530a8e9b4098a8e1e19869a920f9 |
| 出典メモ | uspto-grants-2011_02 |