Hydroxylamine → HCID 178450469、化合物
反応式
[Cl:1][CH2:2][CH2:3][O:4][CH2:5][C:6]([CH3:10])([CH3:9])[C:7]#[N:8].[NH2:11][OH:12]>CCO>[Cl:1][CH2:2][CH2:3][O:4][CH2:5][C:6]([CH3:10])([CH3:9])[C:7]([NH:11][OH:12])=[NH:8]参加物
4
実験手順
3-(2-Chloroethoxy)-2,2-dimethylpropanenitrile (6.1 g, 37.7 mmol) was placed together with 50% aqueous hydroxylamine (3.1 g, 37.7 mmol) in 60 mL EtOH and warmed at 75-80 C with stirring for 18 h. The solution was concentrated and then concentrated further with EtOH and vacuum dried to leave (9.4 g, ˜80% pure) of the title compound as a gum. 1H NMR (300 MHz, CDCl3) δ: 1.17 (s, 6H), 3.40 (s, 2H), 3.58-3.73 (m, 4H), 5.16 (s, 2H). LC/MS (M+H): 195.
後処理
- temperaturewarmed at 75-80 C
- concentrationThe solution was concentrated
- concentrationconcentrated further with EtOH and vacuum
- customdried
出典と根拠
- ORDレコード
- ord-fbf98012bb6748b38b332a880b0b7787
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07893055B2
反応ノート
読み込み中…