2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-(7-Morpholinothiazolo[5,4-d]pyrimidin-5-yl)pyrimidin-2-amine

反応式

Cl[C:2]1[N:3]=[C:4]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[C:5]2[N:10]=[CH:9][S:8][C:6]=2[N:7]=1.CC1(C)C(C)(C)OB([C:25]2[CH:26]=[N:27][C:28]([NH2:31])=[N:29][CH:30]=2)O1>>[O:14]1[CH2:15][CH2:16][N:11]([C:4]2[C:5]3[N:10]=[CH:9][S:8][C:6]=3[N:7]=[C:2]([C:25]3[CH:26]=[N:27][C:28]([NH2:31])=[N:29][CH:30]=3)[N:3]=2)[CH2:12][CH2:13]1

参加物

反応物 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol ester

HCID 576853854-(5-Chlorothiazolo[5,4-d]pyrimidin-7-yl)morpholine

生成物 1

HCID 252547725-(7-Morpholinothiazolo[5,4-d]pyrimidin-5-yl)pyrimidin-2-amine

実験手順

4-(5-Chlorothiazolo[5,4-d]pyrimidin-7-yl)morpholine 14 was reacted with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine via General Procedure A to give 131 after purification by reverse HPLC.

出典と根拠

ORDレコード: ord-f74b0460d38e4712bdc65649735887b8
出典データセット: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07893059B2

反応ノート

読み込み中…