Hydrochloric Acid → 2-Amino-3-(3,4,5-trifluorophenyl)propanoic acid hydrochloride
反応式
C([O:3][C:4](=[O:30])[CH:5]([CH2:20][C:21]1[CH:26]=[C:25]([F:27])[C:24]([F:28])=[C:23]([F:29])[CH:22]=1)[N:6]=C(C1C=CC=CC=1)C1C=CC=CC=1)C.[ClH:31]>O>[ClH:31].[F:27][C:25]1[CH:26]=[C:21]([CH:22]=[C:23]([F:29])[C:24]=1[F:28])[CH2:20][CH:5]([C:4]([OH:30])=[O:3])[NH2:6]参加物
4
実験手順
N-(Diphenylmethylene) (3,4,5-trifluoro)-D,L-Phenylalanine ethyl ester (1.33 g, 3.2 mmol) was suspended in water (15 mL) at 25° C. and treated with conc. hydrochloric acid (5 mL). The mixture was heated at reflux for 4 hrs and evaporated to dryness. The residue was triturated with diethyl ether (4×20 mL). The solid was filtered and dried to afford title compound (0.72 g)
後処理
- temperatureThe mixture was heated
- temperatureat reflux for 4 hrs
- customevaporated to dryness
- customThe residue was triturated with diethyl ether (4×20 mL)
- filtrationThe solid was filtered
- customdried
出典と根拠
- ORDレコード
- ord-9906403db9994456951b6cf66395f98b
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07893020B2
反応ノート
読み込み中…