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HRID 1366作成日：2026年10月25日

Ethyl 3-(bromophenyl)acetate → Ethyl 4-(3-bromophenyl)butanoate

https://huagongshe.com/reaction/1366

反応式

関与物質

役割名称HCID仕込み量
反応物Ethyl 3-(bromophenyl)acetateHCID 11470552—
反応物Ethyl 4-(4-bromophenyl)butanoateHCID 12870375—
生成物Ethyl 4-(3-bromophenyl)butanoateHCID 11492759—

反応手順

Employing the same general multistep preparation as for ethyl4-(4-bromophenyl)butanoate (Compound C), 60 g (246 mmol) of ethyl (3-bromophenyl)acetate (Compound B) was converted into the title compound (oil) using 255 ml (255 mmol) of diisobutylaluminum hydride (DIBAL-H, 1M in hexane), 85.8 g (250 mmol) of (carbethoxymethylene)triphenylphosphorane and 1.7 g of 10% Pd/C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05723666
出典データセットuspto-grants-1998_03
ORD IDord-fd88e66de55049f7ad9914c5bfbadd5a
出典メモuspto-grants-1998_03