2-Bromo-3a,5,6,6a-tetrahydro-furo[2,3-c]pyrrol-4-one → 2-[8-(4-Morpholin-4-yl-phenylamino)-imidazo[1,2-a]pyrazin5-yl]-5,6-dihydro-furo[2,3-c]pyrrol-4-one

反応式

[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14]3[C:15]4[N:16]([CH:27]=[CH:28][N:29]=4)[C:17](C4C=NNC=4C#N)=[CH:18][N:19]=3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(OC(=O)N(C1C=CC(N2CCOCC2)=CC=1)C1C2N(C=CN=2)C([Sn](CCCC)(CCCC)CCCC)=CN=1)(C)(C)C.Br[C:73]1[O:81][CH:76]2[CH2:77][NH:78][C:79](=[O:80])[CH:75]2[CH:74]=1>CN(C=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[N:1]1([C:7]2[CH:8]=[CH:9][C:10]([NH:13][C:14]3[C:15]4[N:16]([CH:27]=[CH:28][N:29]=4)[C:17]([C:73]4[O:81][C:76]5[CH2:77][NH:78][C:79](=[O:80])[C:75]=5[CH:74]=4)=[CH:18][N:19]=3)=[CH:11][CH:12]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1