phenylmethyl (9aR)-octahydro-2H-pyrido[1,2-a]pyrazine-2-carboxylate → (R)-Octahydro-pyrido[1,2-a]pyrazine

HRID 1366596

反応式

HRID 1366596 の反応式
[CH2:1]1[N:6](C(OCC2C=CC=CC=2)=O)[CH2:5][CH2:4][N:3]2[CH2:17][CH2:18][CH2:19][CH2:20][C@H:2]12>CO>[CH2:1]1[NH:6][CH2:5][CH2:4][N:3]2[CH2:17][CH2:18][CH2:19][CH2:20][C@H:2]12

参加物

3

反応物 1

HCID 86636997phenylmethyl (9aR)-octahydro-2H-pyrido[1,2-a]pyrazine-2-carboxylate

生成物 1

HCID 773775(R)-Octahydro-pyrido[1,2-a]pyrazine収率 103.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Phenylmethyl (9aR)-octahydro-2H-pyrido[1,2-a]pyrazine-2-carboxylate (688 mg, 2.50 mmol) was dissolved in MeOH (15 mL), degassed and placed under argon. 10% Pd/C (206 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for 2 h. The contents were then degassed, and the Pd/C was removed by filtration through Celite, washing with MeOH. The filtrate was concentrated in vacuo to provide pure (9aR)-octahydro-2H-pyrido[1,2-a]pyrazine (364 mg, 99%). LCMS: (M+H)+: 141.1.

後処理

  1. customdegassed
  2. addition10% Pd/C (206 mg) was added
  3. customthe contents were thoroughly degassed
  4. customfor 2 h
  5. customThe contents were then degassed
  6. customthe Pd/C was removed by filtration through Celite
  7. washwashing with MeOH
  8. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-9894b32f97834443b64a354cae2c33f8
出典データセット
uspto-grants-2011_02
特許番号
US07893056B2

関連ノート

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