Tris(1,1-dimethylethyl) 2-{2-chloro-5-fluoro-6-[(3-thienylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate → HCID 178514350、化合物

HRID 1366627ノート

反応式

HRID 1366627 の反応式
CC(OC([N:8](C(OC(C)(C)C)=O)[N:9]([C:17]1[C:22]([F:23])=[C:21]([NH:24][CH2:25][C:26]2[CH:30]=[CH:29][S:28][CH:27]=2)[N:20]=[C:19]([Cl:31])[N:18]=1)C(OC(C)(C)C)=O)=O)(C)C>CO.Cl>[Cl:31][C:19]1[NH:20][C:21]([NH:24][CH2:25][C:26]2[CH:30]=[CH:29][S:28][CH:27]=2)=[C:22]([F:23])[C:17](=[N:9][NH2:8])[N:18]=1

参加物

4

反応物 1

HCID 86637009Tris(1,1-dimethylethyl) 2-{2-chloro-5-fluoro-6-[(3-thienylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate

生成物 1

HCID 178514350HCID 178514350、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

Tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[(3-thienylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (1.6214 g, 2.83 mmol) was dissolved in MeOH (28 mL) and HCl (4M in 1,4-dioxane) (28 mL). The reaction mixture was left to stir overnight and then evaporated to provide 2-chloro-5-fluoro-6-[(3-thienylmethyl)amino]-4(1H)-pyrimidinone hydrazone, presumed dihydrochloride, as a wine colored solid (1.0828 g). LCMS: (M+H−2HCl)+=273.9.

後処理

  1. waitThe reaction mixture was left
  2. customevaporated

出典と根拠

ORDレコード
ord-dd05b5a6f42b492fbbf6bd36566edec6
出典データセット
uspto-grants-2011_02
特許番号
US07893056B2

反応ノート

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