HCID 66936334、化合物 → HCID 55288067、化合物
反応式
[CH3:1][N:2]1[CH2:7][C@@H:6]([CH3:8])[N:5](CC2C=CC=CC=2)[CH2:4][C@H:3]1[CH3:16]>CO>[CH3:1][N:2]1[CH2:7][C@@H:6]([CH3:8])[NH:5][CH2:4][C@H:3]1[CH3:16]参加物
3
実験手順
(2R,5R)-1,2,5-Trimethyl-4-(phenylmethyl)piperazine (680 mg, 3.11 mmol) was dissolved in 50 mL of MeOH, degassed and placed under argon. 10% Pd/C (170 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for approximately 3 hrs. The contents were then degassed and filtered through Celite, and the Celite pad was washed with DCM and MeOH. After 6.5 mL 1N HCl was added, the resulting filtrate was concentrated in vacuo to provide the hydrochloride salt of (2R,5R)-1,2,5-trimethylpiperazine (251 mg, 100%). LCMS: (M+H)+: 129.1.
後処理
- customdegassed
- addition10% Pd/C (170 mg) was added
- customthe contents were thoroughly degassed
- customfor approximately 3 hrs
- customThe contents were then degassed
- filtrationfiltered through Celite
- washthe Celite pad was washed with DCM and MeOH
- additionAfter 6.5 mL 1N HCl was added
- concentrationthe resulting filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-0025c7cdb0af4412abb76d77aa9f27b8
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07893056B2
反応ノート
読み込み中…