HCID 66936015、化合物 → (4Ar,8as)-1-methyldecahydroquinoxaline

HRID 1366660ノート

反応式

HRID 1366660 の反応式
[CH3:1][N:2]1[C@@H:11]2[C@@H:6]([CH2:7][CH2:8][CH2:9][CH2:10]2)[N:5](C(OCC2C=CC=CC=2)=O)[CH2:4][CH2:3]1>CO>[CH3:1][N:2]1[C@@H:11]2[C@@H:6]([CH2:7][CH2:8][CH2:9][CH2:10]2)[NH:5][CH2:4][CH2:3]1

参加物

3

反応物 1

HCID 66936015HCID 66936015、化合物

生成物 1

HCID 231577(4Ar,8as)-1-methyldecahydroquinoxaline収率 144.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Phenylmethyl (4aS,8aR)-4-methyloctahydro-1(2H)-quinoxalinecarboxylate (2.7 g, 9.4 mmol) was dissolved in 140 mL of MeOH, degassed and placed under argon. 10% Pd/C (400 mg) was added, and the contents were thoroughly degassed and placed under a hydrogen balloon for approximately 2 hrs. The contents were then degassed and filtered through Celite, and the Celite pad was washed with DCM and MeOH. After 19.6 mL 1N HCl was added, the resulting filtrate was concentrated in vacuo to provide the hydrochloride salt of (4aR,8aS)-1-methyldecahydroquinoxaline (2.1 g, 100%). LCMS: (M+H)+: 155.1.

後処理

  1. customdegassed
  2. addition10% Pd/C (400 mg) was added
  3. customthe contents were thoroughly degassed
  4. customfor approximately 2 hrs
  5. customThe contents were then degassed
  6. filtrationfiltered through Celite
  7. washthe Celite pad was washed with DCM and MeOH
  8. additionAfter 19.6 mL 1N HCl was added
  9. concentrationthe resulting filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-2207c62860274943abe7e9e2ad90d50e
出典データセット
uspto-grants-2011_02
特許番号
US07893056B2

反応ノート

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