Tris(1,1-dimethylethyl) 2-{2-chloro-5-fluoro-6-[(1,3-thiazol-4-ylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate → HCID 178514351、化合物
反応式
CC(OC([N:8](C(OC(C)(C)C)=O)[N:9]([C:17]1[C:22]([F:23])=[C:21]([NH:24][CH2:25][C:26]2[N:27]=[CH:28][S:29][CH:30]=2)[N:20]=[C:19]([Cl:31])[N:18]=1)C(OC(C)(C)C)=O)=O)(C)C>CO.Cl>[Cl:31][C:19]1[NH:20][C:21]([NH:24][CH2:25][C:26]2[N:27]=[CH:28][S:29][CH:30]=2)=[C:22]([F:23])[C:17](=[N:9][NH2:8])[N:18]=1参加物
4
実験手順
Tris(1,1-dimethylethyl)2-{2-chloro-5-fluoro-6-[(1,3-thiazol-4-ylmethyl)amino]-4-pyrimidinyl}-1,1,2-hydrazinetricarboxylate (0.51 g, 0.8868 mmol) was dissolved in MeOH (5 mL) and HCl (4M in 1,4-dioxane) (5 mL). The reaction mixture was left to stir overnight, then evaporated and purified by RP-HPLC to provide 2-chloro-5-fluoro-6-[(1,3-thiazol-4-ylmethyl)amino]-4(1H)-pyrimidinone hydrazone as an orange oil (0.105 g). LCMS: (M+H)+=275.0.