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Diethyl Ether → 1-[5-(3-Chlorophenyl)-2-furyl]ethan-1-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 5-(3-Chlorophenyl)furfural | HCID 609822 | — |
| 反応物 | HCID 178418689 | HCID 178418689 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-[5-(3-Chlorophenyl)-2-furyl]ethan-1-ol | HCID 62498593 | — |
反応手順
To a solution of 5-(3-chlorophenyl)furan-2-carbaldehyde (1.0 equiv.) in THF at 0° C. was added MeMgBr in ether (3.0 equiv.) and stirred for 45 min. The reaction was quenched with water, diluted with ether and filtered through Celite. The organic layer was separated and washed with brine, dried over MgSO4, and concentrated to give the 1-[5-(3-chlorophenyl)-2-furyl]ethan-1-ol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07893096B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-ef510c6e17114ee2bb54dac234e3a116 |
| 出典メモ | uspto-grants-2011_02 |