Triethylamine → HCID 86649015、化合物

反応式

[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([OH:11])[CH2:8][C@H:7]1[C:12]([N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)=[O:13])=[O:5])[CH3:2].C(N(CC)CC)C.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>ClCCl>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][C@H:9]([O:11][S:28]([CH3:27])(=[O:30])=[O:29])[CH2:8][C@H:7]1[C:12]([N:14]1[CH2:15][CH2:16][O:17][CH2:18][CH2:19]1)=[O:13])=[O:5])[CH3:2]

参加物

実験手順

To a solution of (1R,2R,4R)-4-hydroxy-2-(morpholine-4-carbonyl)-cyclopentanecarboxylic acid ethyl ester (1.0 mmol) in dichloromethane (5 ml) was added at 5° C. triethylamine (2.2 mmol) and methanesulfonyl chloride (2.2 mmol) and stirring was continued for 1 h. The mixture was partitioned between 1 N aqueous HCl and ethyl acetate, the organic layer was dried, evaporated and chromatographed on silica using ethyl acetate to give (1R,2R,4R)-4-methanesulfonyloxy-2-(morpholine-4-carbonyl)-cyclopentanecarboxylic acid ethyl ester as a colorless oil. MS: 350.4 (M+H)+.