Triethyl orthoacetate → 3-(3,4-dichlorophenyl)-2-methylquinazolin-4-one
反応式
[NH2:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([Cl:14])[CH:8]=1)=[O:5].[CH2:19](OC(OCC)(OCC)C)[CH3:20]>O>[CH3:19][C:20]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([Cl:14])[CH:8]=2)[C:4](=[O:5])[C:3]2[C:2](=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:1]=1参加物
4
実験手順
A mixture of 62 (2.8 g, 0.009 mol) and 1,1,1-triethoxy-ethane (5.2 mL, 0.028 mol) were heated for 5 hours. The reaction mixture was poured into water, filtered, washed with water yielding compound 63 (55%). After recrystallization from EtOH, the material was used in next step without further purification.
後処理
- temperaturewere heated for 5 hours
- filtrationfiltered
- washwashed with water yielding compound 63 (55%)
- customAfter recrystallization from EtOH
- customthe material was used in next step without further purification
出典と根拠
- ORDレコード
- ord-f45f5321e6ea47918a960028639ea56f
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07893260B2
反応ノート
読み込み中…