Bromine → Methyl 2-amino-5-bromo-3-nitrobenzoate

HRID 1367934ノート

反応式

HRID 1367934 の反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[NH2:13].[Br:15]Br>C(O)(=O)C>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([Br:15])[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]=1[NH2:13]

参加物

4

反応物 2

HCID 24408BromineHCID 607264Methyl 2-amino-3-nitrobenzoate

生成物 1

HCID 17984898Methyl 2-amino-5-bromo-3-nitrobenzoate収率 87.4%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a solution of 2.23 g (10.4 mmol) of 2-amino-3-nitro-benzoic acid methyl ester in 12 mL of acetic acid was added dropwise a solution of 0.53 mL (10.4 mmol) of Br2 in 2.0 mL of acetic acid. The mixture was stirred at r.t. for 30 min and poured into 100 g of ice. The solid was collected by filtration and dried to afford 2.5 g (82%) of 2-Amino-5-bromo-3-nitro-benzoic acid methyl ester. 1H NMR (CDCl3, 400 MHz): δ 8.6 (d, 1H), 8.53 (s, 1H), 3.95 (s, 3H) ppm.

後処理

  1. filtrationThe solid was collected by filtration
  2. customdried

出典と根拠

ORDレコード
ord-77c2743c3c924185ae8d1f4cf72dd17d
出典データセット
uspto-grants-2011_02
特許番号
US07893267B2

反応ノート

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