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Acetyl chloride → 5-Bromo-4-chloroisatoic anhydride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Ethyl chloroformate | HCID 10928 | — |
| 反応物 | 2-Amino-5-bromo-4-chlorobenzoic acid | HCID 19612050 | — |
| 生成物 | 5-Bromo-4-chloroisatoic anhydride | HCID 86608392 | 70% |
反応手順
7.5 g (30 mmol) of 2-amino-5-bromo-4-chloro-benzoic acid was heated under reflux with 18 mL of ethyl chloroformate for 6 h, and was further heated under reflux for another 3 h after addition of 18 mL of acetyl chloride. The solid was collected and washed with hexanes to produce 5.8 g (70%) of 5-bromo-4-chloroisatoic anhydride. LCMS: 277 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07893267B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-0c0d4bbab2b2488593fe27b1cc1022b6 |
| 出典メモ | uspto-grants-2011_02 |