4-(4-Chlorophenyl)-4-hydroxypiperidine → 37743-37-6

HRID 1368332ノート

反応式

HRID 1368332 の反応式
[Cl:1][CH2:2][CH2:3][C:4]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:5]([NH:7][CH3:8])=[O:6].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2([OH:34])[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:24][CH:23]=1>C(C(C)=O)C(C)C>[ClH:1].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2([OH:34])[CH2:29][CH2:30][N:31]([CH2:2][CH2:3][C:4]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:5]([NH:7][CH3:8])=[O:6])[CH2:32][CH2:33]2)=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 382824-(4-Chlorophenyl)-4-hydroxypiperidineHCID 18520143HCID 18520143、化合物

生成物 1

HCID 980594337743-37-6収率 35%

試薬・触媒・溶媒 1

HCID 7909Methyl Isobutyl Ketone溶媒

実験手順

A suspension of 4-chloro-N-methyl-2,2-diphenylbutyramide (1.4 g, 0.005 mol), 4-p-chlorophenyl-4-piperidinol (2.12 g, 0.01 mol), and trace Kl in i-BuCOMe (50 ml) was refluxed for 12 hrs. The reaction mixture was worked-up as described in Example 16 to provide 4-(p-chlorophenyl)-4-hydroxy-N-methyl-α,α-diphenyl-1-piperidinebutyramide hydrochloride (0.8 g, 35%), mp 236-238° C.

後処理

  1. temperaturewas refluxed for 12 hrs

出典と根拠

ORDレコード
ord-363421b8dde54f9db96d12e871bba944
出典データセット
uspto-grants-2003_06
特許番号
US06573282B1

反応ノート

読み込み中…