1-(6-Acetoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol → HCID 178475354、化合物

HRID 1368523ノート

反応式

HRID 1368523 の反応式
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([C:20]1[N:21]=[CH:22][N:23](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:24]=1)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:9]=[CH:8]2)(=[O:3])[CH3:2]>C(O)(=O)C.[C].[Pd]>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]([C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)([OH:19])[CH:16]([CH3:18])[CH3:17])[CH:9]=[CH:8]2)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 220183421-(6-Acetoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

生成物 1

HCID 178475354HCID 178475354、化合物収率 69.9%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 176Acetic Acid溶媒

反応条件

温度
50 °C

実験手順

1-(6-Acetoxynaphthalen-2-yl)-1-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol (0.25 g) was dissolved in acetic acid (20 ml). To the mixture was added 10% palladium carbon (0.1 g). The mixture was stirred at 50° C. for 2 h under hydrogen atmosphere. The catalyst was filtered off, and filtrate was concentrated. The residue was purified by silica gel chromatography (eluent; dichloromethane-methanol=10:1) to give the titled compound (0.1 g) as a colorless solid.

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationfiltrate was concentrated
  3. customThe residue was purified by silica gel chromatography (eluent; dichloromethane-methanol=10:1)

出典と根拠

ORDレコード
ord-294df26305144dcbba769b9e9633acc5
出典データセット
uspto-grants-2003_06
特許番号
US06573289B1

反応ノート

読み込み中…