化工社化工社 化学情報印刷レポート · 研究参考用
Pyrazole → 5-Pyrazol-1-yl-indan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrazole | HCID 1048 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Fluoro-1-indanone | HCID 136537 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 5-Pyrazol-1-yl-indan-1-one | HCID 55272722 | 73% |
反応手順
Combine 5-fluoro-indan-1-one (1.02 g, 6.79 mmol), pyrazole (0.46 g, 6.79 mmol), and potassium carbonate (1.03 g, 7.47 mmol, 1.10 equivalents) in dimethyl sulfoxide (5 ml) in a sealed tube and heat to 100° C. for 48 hours. Cool to room temperature, dilute with ether, wash with water (2×), dry over anhydrous sodium sulfate, and concentrate to obtain the title compound as a brown solid (0.98 g, 73%). LC-MS m/z 199.1 (M++1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728150B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-f4d7115efd174a5987f52d7c0fd3251e |
| 出典メモ | uspto-grants-2010_06 |