Malonic Acid → 3-Amino-3-(4-(trifluoromethoxy)phenyl)propanoic acid
反応式
[F:1][C:2]([F:13])([F:12])[O:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1.[C:14]([OH:20])(=[O:19])[CH2:15]C(O)=O.C([O-])(=O)C.[NH4+:25]>C(O)C>[NH2:25][CH:8]([C:7]1[CH:10]=[CH:11][C:4]([O:3][C:2]([F:13])([F:12])[F:1])=[CH:5][CH:6]=1)[CH2:15][C:14]([OH:20])=[O:19]参加物
5
実験手順
10.5 g of 4-(trifluoromethoxy)benzaldehyde, 5.72 g of malonic acid, 8.5 g of ammonium acetate and 40 ml of ethanol are boiled under reflux for 8 hours and stirred at room temperature overnight. The cooled reaction mixture is then filtered with suction, washed with ethanol and ether and dried in air. 3-amino-3-(4-trifluoromethoxyphenyl)propionic acid is obtained, melting point 258-260°.
後処理
- temperatureunder reflux for 8 hours
- customThe cooled reaction mixture
- filtrationis then filtered with suction
- washwashed with ethanol and ether
- customdried in air
出典と根拠
- ORDレコード
- ord-f0605d84d90b43599d714c85a74a8d39
- 出典データセット
- uspto-grants-2003_06
- 特許番号
- US06576637B1
反応ノート
読み込み中…