Ammonium Chloride → Ethyl 3-methyl-4H-thieno[3,2-B]pyrrole-5-carboxylate

HRID 1368985ノート

反応式

HRID 1368985 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=O)[S:5][CH:6]=1.[CH2:9]([O:11][C:12](=[O:17])[CH2:13][N:14]=[N+]=[N-])[CH3:10].[NH4+].[Cl-]>C(O)C>[CH2:9]([O:11][C:12]([C:13]1[NH:14][C:3]2[C:2]([CH3:1])=[CH:6][S:5][C:4]=2[CH:7]=1)=[O:17])[CH3:10]

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 69480Acetic acid, azido-, ethyl esterHCID 27955264-methylthiophene-2-carbaldehyde

生成物 1

HCID 11651387Ethyl 3-methyl-4H-thieno[3,2-B]pyrrole-5-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Methyl-thiophene-2-carbaldehyde (Detty, M. R.; Hays, D. S., Heterocycles, 40: 925-37 (1995)) was annulated according to Procedure H (aldehyde and azido-acetic acid ethyl ester added as ethanol solution (1.1 M of ester); reaction poured into cold saturated aqueous NH4Cl; after ether extractions, acrylate organic phase washed with water until aqueous phase was neutral; acrylate not purified).

後処理

  1. customreaction
  2. extractionafter ether extractions, acrylate organic phase
  3. washwashed with water until aqueous phase
  4. customacrylate not purified)

出典と根拠

ORDレコード
ord-5a19c35d777a4a70ba316e3cdbb1c2f3
出典データセット
uspto-grants-2003_06
特許番号
US06576653B2

反応ノート

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