1-Chloro-2-(diethylamine)ethane hydrochloride → HCID 18518556、化合物

反応式

[I:1][C:2]1[CH:3]=[CH:4][C:5]([C:13]([F:16])([F:15])[F:14])=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[C:7]2=[O:12].Cl.Cl[CH2:19][CH2:20][N:21]([CH2:24][CH3:25])[CH2:22][CH3:23]>>[CH2:20]([N:21]([CH2:24][CH3:25])[CH2:22][CH2:23][N:9]1[C:10]2[C:6](=[C:5]([C:13]([F:16])([F:14])[F:15])[CH:4]=[CH:3][C:2]=2[I:1])[C:7](=[O:12])[C:8]1=[O:11])[CH3:19]

参加物

反応物 2

HCID 133631-Chloro-2-(diethylamine)ethane hydrochloride

HCID 185185657-Iodo-4-(trifluoromethyl)-1H-indole-2,3-dione

生成物 1

HCID 18518556HCID 18518556、化合物収率 76%

実験手順

The title compound (245 mg, 76%) was prepared from 7-iodo-4-trifluoromethylisatin (250 mg, 0.733 mmol) and 2-chloroethyl-N,N-diethylamine hydrochloride by the procedure similar to that described in Reference Example 8.

出典と根拠

ORDレコード: ord-87bbbd34d8ff45f6ae6e74038e6e60ec
出典データセット: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06576656B1

反応ノート

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