1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodoisatin → 1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(phenyl)oxindole
反応式
[CH2:1]([N:3]([CH2:22][CH3:23])[CH2:4][CH2:5][N:6]1[C:16]2[C:11](=[C:12]([C:18]([F:21])([F:20])[F:19])[CH:13]=[C:14]([I:17])[CH:15]=2)[C:9](=[O:10])[C:7]1=[O:8])[CH3:2].[C:24]1([Mg]Br)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:22]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:16]2[C:11](=[C:12]([C:18]([F:20])([F:21])[F:19])[CH:13]=[C:14]([I:17])[CH:15]=2)[C:9]([OH:10])([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:7]1=[O:8])[CH3:23]参加物
3
実験手順
The title compound (53%) was prepared from 1-(2-diethylaminoethyl)-6-iodo-4-trifluoromethylisatin and phenylmagnesium bromide by the procedure similar to that described in Example 1. The compound obtained was further purified by reverse phase HPLC with water-acetonitrile-trifluoroacetic acid.
後処理
- customThe compound obtained
- customwas further purified by reverse phase HPLC with water-acetonitrile-trifluoroacetic acid