Hydrochloric Acid → Racivir

HRID 1369178ノート

反応式

HRID 1369178 の反応式
[CH2:1]1[S:5][C@H:4]([CH2:6][OH:7])[O:3][C@@H:2]1[N:8]1[C:13](=[O:14])[N:12]=[C:11]([NH2:15])[C:10]([F:16])=[CH:9]1.Cl>CO.O1CCOCC1>[NH2:15][C:11]1[C:10]([F:16])=[CH:9][N:8]([CH:2]2[O:3][CH:4]([CH2:6][OH:7])[S:5][CH2:1]2)[C:13](=[O:14])[N:12]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 60877Emtricitabine

生成物 1

HCID 9837769Racivir

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

反応条件

温度
0 °C

実験手順

A mixture of (−)-FTC [32 (2R, β/α)] (60:40 of a β:α anomer mixture, 3.0 g) was dissolved in methanol (30 ml), cooled to 0° C., and treated with a 4.0 M solution of HCl in 1,4-dioxane (3.3 ml [1.1×]). The solution was stirred for 20 minutes, and subsequently concentrated to dryness affording an off-white solid.

後処理

  1. concentrationsubsequently concentrated to dryness
  2. customaffording an off-white solid

出典と根拠

ORDレコード
ord-74ef42652563429cb307fe78edf3d3c8
出典データセット
uspto-grants-2003_06
特許番号
US06576776B1

反応ノート

読み込み中…