2,5-Diamino-2-methylpentanoic acid hydrochloride → 2-Amino-5-[[1-(hydroxyimino)ethyl]amino]-2-methylpentanoic Acid, Dihydrochloride
反応式
[ClH:1].[CH3:2][C:3]([C:9]([OH:11])=[O:10])([CH2:5][CH2:6][CH2:7][NH2:8])[NH2:4].[Cl:12][CH2:13][CH:14]=[N:15][OH:16]>O>[ClH:12].[ClH:1].[NH2:4][C:3]([CH3:2])([CH2:5][CH2:6][CH2:7][NH:8][C:14](=[N:15][OH:16])[CH3:13])[C:9]([OH:11])=[O:10]参加物
4
実験手順
α-Methyl-D,L-ornithine hydrochloride is protected as a copper complex via reaction with cupric carbonate in water at reflux. This protected amino acid is then reacted with chloroacetaldoxime as in Example 1. The product is eluted from Dowex with 1N ammonium hydroxide. Concentration in vacuo, followed by acidification with hydrochloric acid affords the title compound.
後処理
- temperatureat reflux
- washThe product is eluted from Dowex with 1N ammonium hydroxide
- concentrationConcentration in vacuo
出典と根拠
- ORDレコード
- ord-eb06487868184bf3ac67696b73a3afeb
- 出典データセット
- uspto-grants-2003_06
- 特許番号
- US06576780B1
反応ノート
読み込み中…