化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine → n-(1h-Indol-7-yl)methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 7-Aminoindole | HCID 111634 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | n-(1h-Indol-7-yl)methanesulfonamide | HCID 20231824 | 94% |
反応手順
Stir 1H-indol-7-ylamine with pyridine (1 equivalent) and methanesulfonyl chloride (1 equivalent) in dichloromethane for 12 hrs. Wash the reaction with 1N hydrochloric acid and water, dry over magnesium sulfate, and evaporate. Recrystallize the residue from isopropanol to obtain the title product as a purple solid (94%). MS (ES+), 210 (M), MS (ES−), 209 (M−1). LC/MS shows 95% purity.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07728150B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-54e3deaf4b5a4dd0936ca7f5174fa939 |
| 出典メモ | uspto-grants-2010_06 |